Blog
Cardiovascular disease in the workplace: how to leverage data-driven solutions to the biggest health challenge facing employers
In today’s fast-paced corporate landscape, the health and well-being of employees are paramount for sustained productivity and success. One of the most prevalent health challenges facing workplaces is cardiovascular disease, particularly...
Five Considerations for Selecting a Workplace Wellness Program: How to Achieve Strong ROI for Employers & Long-Term Benefits for Employees
In the fast-paced world of business, ensuring the well-being of employees has become a top priority for innovative employers. A successful wellness program not only fosters a culture of healthier and happier employees, but also yields impressive returns...
How to ensure lasting employee engagement in your workplace health program
Maintaining a healthy and engaged workforce is a cornerstone of a successful organization. Workplace health programs not only enhance the well-being of employees but also contribute to increased productivity, reduced absenteeism, and...
Using polygenic risk scores to enhance cardiovascular disease risk prediction
Cardiovascular diseases — a general term for a suite of diseases that affect the heart or blood vessels — account for one in three deaths globally and are a major drain on public health spending. Our risk of cardiovascular disease increases as we age...
How to superpower a clinical trial with PRS
Clinical trials are an essential part of the pharmaceutical industry, but they face many challenges. One of the significant obstacles is the high rate of failure, with over 90% of drug candidates that...
PRS & Shared Decision Making
A valid question that is often asked when discussing PRS implementation is “how will this information be used in clinical care in the absence of clinical guidelines for PRS”? One approach is to ensure PRS risk information is presented in a way that...
NSGC’s PRS Practice Resource: Your PRS one-stop shop
This year was kicked off by the publication of the NSGC Practice Resource for Clinical Counseling/Translation of Polygenic Scores, put together by Wand et al. — a stellar team of leaders in the PRS field.
PRS-powered disease risk reporting
We’ve previously written about how you can use Allelica’s DISCOVER software to build new polygenic risk scores (PRS) and to deploy them at scale with PREDICT. While a PRS provides…
Harnessing the power of PRS by combining standardized reporting with Allelica’s software
This week, scientists from the Clinical Genome Resource (ClinGen) Complex Disease Working Group and the Polygenic Score (PGS) Catalog published a paper in Nature introducing…
Understanding the link between genetics, cholesterol and coronary artery disease
Cardiovascular disease is the leading cause of death worldwide, with recent estimates putting the global death toll at around 18 million each year. It is also a major burden on populations and health systems, contributing to…
The PREDICT Module: Unlocking the power of genomics
In our previous articles on Allelica’s PRS pipeline, we ran through how you can use our DISCOVER module to build your own PRS for a disease or trait of interest, as well as how our VALIDATE module can be used to test the predictive power of…
The VALIDATE module: Quantifying the power of PRS
Essential testing of your PRS on an independent population. In our previous articles outlining Allelica’s PRS pipeline we described how users can impute genotype or…
The DISCOVER Module: Seamlessly building new polygenic risk scores
A user friendly, cloud-based computing solution to build state-of-the-art, publication ready polygenic risk scores. The DISCOVER moduleallows users to build their own polygenic risk…
The IMPUTE Module: Enriching Low-Coverage and Microarray data
Fast and scalable genome imputation of Low-Coverage WGS and Microarray data in just minutes. Allelica’s PRS pipeline is built around a set of interconnected modules…
Coronary Artery Disease: Predicting risk through genetics
Within the last two decades, and upon completion of the world’s largest biological project in 2003, interest in the human genome and its effect on…
Large Scale Genomics Datasets In the UK
We previously wrote about the enormous impact that the UK Biobank (UKBB) is having to translational research. Although the scientific outputs from this project are now beginning…
Genetics is actionable
In Allelica we’re very excited about the incredible advances that analyses of large DNA datasets are bringing to medicine. In addition to the increasingly…
Beyond BRCA
Vast quantities of human DNA have been sequenced for biomedical research and clinicians, researchers and innovators are now beginning to focus on the next phase of the genomic revolution: translating these data into tools...
Disease is Polygenic
In the late 19th Century, a Moravian monk named Gregor Mendel passed his time by running experiments cross-breeding different types of pea plant. Amongst his…
